Latest News

Diabetes Care publishes special issue,​​​​​​​ April 2024 featuring ten new articles with important findings from GRADE​​​​​

Analysis of cardiovascular outcomes confirm modest superiority of liraglutide among people with T2DM at relatively low cardiovascular risk

In GRADE, overall prevalence of retinopathy increased slightly over time, but there were no differences across the 4 study medications

We measured GAD-65 antibodies in a subgroup of GRADE participants and found no association with β-cell dysfunction in GRADE

We observed no difference in kidney outcomes over 5 years across participants randomized to one of 4 glucose-lowering medications added to metformin

The GRADE study was recognized as one of the 2023 Top 10 Clinical Research Achievements by the Clinical Research Forum

NIDDK Press Release on
​​​​​​​GRADE Main Study Results –
Wednesday, September 21, 2022

Islet Autoimmunity Is Highly Prevalent and Associated With Diminished b-Cell Function in Patients With Type 2 Diabetes

At home “Capillary kits” were developed and used by participants for self-collections of blood and validated for HbA1c testing in the GRADE Study

In GRADE, enrollment goals were met to achieve a nationally representative cohort of the US population of individuals with T2DM less than 10 years duration

GRADE Publications

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GRADE Publications


Additional publications are attributed to the GRADE grant numbers through the National Library of Medicine, but were not authored by, nor published on behalf of, the GRADE study.

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